Effects of Dienogest and Dienogest Plus Estradiol Valerate in Ovarian Endometrioma
Status:
Unknown status
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
Progesterone resistance in endometriosis is a known fact. The progestin derivatives used in
endometriosis cause decidualization and atrophy of ectopic foci. Moreover, they inhibit
neo-angiogenesis, provide suppress expansile/destructive growth facilitated by matrix
metalloproteinases, and implantation of ectopic foci. The effect of drugs containing the
estrogen-progesterone combination is mainly based on the inhibition of ovulation,
decidualization and atrophy of ectopic foci. In estrogen-progesterone mechanism, it is known
that estrogen has a progesterone receptor-enhancing effect, which may make progesterone more
potent. Based on this, the investigators hypothesized that estrogen added to progesterone
could lead to a further reduction in endometrioma size by various mechanisms which probably
include the increased progesterone sensitivity in endometriosis. In addition, the
investigators hypothesized that this therapy can alleviate the destructive effect of
endometriomas on the ovarian reserve.
Phase:
Phase 4
Details
Lead Sponsor:
Bagcilar Training and Research Hospital
Collaborators:
Kocaeli Derince Education and Research Hospital Suleymaniye Birth And Women's Health Education And Research Hospital