Effects of Dietary Conditions on Drug Response

• Status: Recruiting
• Trial end date: 2023-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This non-treatment study will examine how different dietary conditions may affect a person's response to commonly used drugs.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Johns Hopkins University
• Collaborator: National Institute on Drug Abuse (NIDA)

Criteria

Inclusion Criteria:

• Age 18-45 years

• Fluent in written and spoken English and is capable of understanding and complying with the protocol

• Medically healthy

• Non-smoker

• Appropriate dietary/over-the-counter/prescription/illicit drug use history

• Body Mass Index between 18.5 and 34.9

• Appropriate use of birth control in females e.g., barrier methods, hormonal contraceptives, Intra Uterine Devices (IUDs)

Exclusion Criteria:

• Known hypersensitivity to administered drugs

• Current neurological, hepatic, renal, endocrine, cardiovascular, gastrointestinal, pulmonary or metabolic disease for which administration of the study drugs would be contraindicated

• Current psychiatric or substance use condition that would interfere with study participation

• Diastolic blood pressure >90 mmHg or a systolic pressure of >140 mmHg

• Use of medications that would interfere with study participation

• Unwilling or unable to comply with the protocol

• Any other serious disease or condition that might affect life expectancy or make it difficult to successfully manage the subjects according to the protocol

• Females: Pregnancy, breastfeeding, or plans to become pregnant