Effects of Different Concentrations of Pressurized-heparin Flushing Fluid on Coagulation and Platelet Function Monitored by the Sonoclot Analyzer

• Status: Completed
• Trial end date: 2019-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Heparin diluent or normal saline is generally used as the arterial tube flushing in clinical practice, but there is no consensus on the choice of flushing fluid. Heparin can affect the blood coagulation function, and even lead to heparin-related thrombocytopenia, increasing the risk of perioperative embolism. Sonoclot is a blood viscoelasticity test, which can provide comprehensive information on the coagulation's cascade and the entire process and be quicker and more effective than routine laboratory coagulation tests. In this research, the coagulation and platelet function analyzer called Sonoclot is used to evaluate the effect of different concentrations of pressurized heparin on the coagulation and platelet function of perioperative patients, which can provide a reference for the clinical choice of appropriate arterial flushing.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Yangzhou University
• Treatments: Calcium heparin; Heparin

Criteria

Inclusion Criteria:

• Diagnosis of gastrointestinal cancer

• Ages ranged from 18 to 75

• ASA I~III

Exclusion Criteria:

• Pregnancy

• modified Allen Test negative

• history of taking anti-platelet drugs such as aspirin one week before surgery, heparin allergy and thrombotherapy

• two failed catheterizations of the same artery

• significant diseases in liver and kidney function

• refusal of patients