Effects of Different Doses of Vitamin D on Cancer-related Cognitive Impairment in Patients With Gastrointestinal Tumors

• Status: Not yet recruiting
• Trial end date: 2022-12-30
• Target enrollment: 0
• Participant gender: All

Summary

To explore the effect of different doses of vitamin D drugs on gastrointestinal cancer cancer-related cognitive impairment, so as to provide reference and basis for the clinical use of our cognitive function surgery nursing plan for patients with gastrointestinal cancer.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yangzhou University
• Collaborator: Subei People's Hospital of Jiangsu Province
• Treatments: Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Patients with gastrointestinal tumors diagnosed by gastroscopy and histology and their family members

• Elective surgery

• Education level in primary school or above

• Be able to fill in the questionnaire alone or under the guidance of the researcher

• Informed consent and voluntary participation in this study

Exclusion Criteria:

• Patients with cognitive impairment (illiteracy less than 17 points, primary school less than 20 points, secondary school or above less than 24 points) or previous history of cognitive impairment, dementia and delirium confirmed by MMSE examination before surgery

• Patients with life-threatening acute and chronic diseases

• Patients with eye or ear diseases leading to rapid loss of hearing or vision without AIDS

• Patients who have taken drugs related to improving cognitive function or drugs for psychiatric disorders

• Patients who cannot take care of themselves or are physically disabled and unable to perform neurological function tests

• Intraoperative hypoxemia (blood oxygen saturation < 94％) more than 10 minutes

• Patients who quit or died due to non-cooperation or emergency