Effects of Different Omeprazole Dosing on Gastric pH in Non-variceal Upper Gastrointestinal Bleeding

• Status: Completed
• Trial end date: 2013-06-08
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to identify the best method of omeprazole (OME) application with respect to intragastric pH, cytochrome P450 2C19 (CYP2C19) genotype and phenotype.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical University of Bialystok
• Collaborator: National Science Centre, Poland
• Treatments: Omeprazole

Criteria

Inclusion Criteria:

• written informed consent must be obtained before any treatment or assessment is performed

• patients admitted with upper gastrointestinal bleeding (UGIB) symptoms to the Emergency Department of the University Hospital of Bialystok (Bialystok, Poland)

Exclusion Criteria:

• pregnancy

• age >90 years

• lack of written consent

• recent treatment with certain medications, including PPIs, H2-receptor antagonists (H2RA), antacids, steroids, oral contraceptives, clopidogrel, prasugrel and clarithromycin

• the presence of variceal UGIB

• history of surgery of upper gastro-intestinal tract