Effects of Different Types of Perioperative Analgesia on Minimal Residual Disease Development After Colon Cancer Surgery
Status:
Completed
Trial end date:
2019-03-01
Target enrollment:
Participant gender:
Summary
The aim of this study is to compare the effects of three types of perioperative analgesia on
the number of circulating cancer cells (representing minimal residual disease) following
radical colon cancer surgery. Patients will be randomized into one of three groups. The
intervention group will receive combined regional and general anesthesia during surgery and
postoperative epidural analgesia. The two control groups will receive balanced general
anesthesia and either morphine-based or piritramide-based postoperative analgesia. We
hypothesize that epidural analgesia will be favorable to both piritramide-based and
morphine-based analgesia and that piritramide-based analgesia will be favorable to
morphine-based analgesia with regard to the number of circulating cancer cells and its
development in the early postoperative period.
Phase:
Phase 4
Details
Lead Sponsor:
The Institute of Molecular and Translational Medicine, Czech Republic
Collaborators:
Brno University Hospital Tomas Bata Hospital, Czech Republic