Effects of Dobutamine on Microcirculation, Regional and Peripheral Perfusion in Septic Shock Patients

• Status: Completed
• Trial end date: 2013-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators hypothesize that dobutamine is able to revert negative redistribution of flow by inducing a selective vasodilatory effect on hypoperfused territories, particularly at the sublingual and gastric mucosa, and at the peripheral tissues.

The investigators designed a randomized, cross-over, placebo-controlled study looking at the acute physiologic effects of 5 mcg/kg/min fixed-dose of dobutamine on cardiac function, microcirculation, gastric mucosal, hepatosplanchnic, and peripheral perfusion in septic shock patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pontificia Universidad Catolica de Chile
• Treatments: Dobutamine

Criteria

Inclusion Criteria:

• Adult patients (>18 years)

• Septic shock for less than 24 hours

• Arterial lactate > 2.4 mmol/l

• Mechanical ventilation and pulmonary artery catheter in place

Exclusion Criteria:

• Pregnancy

• Refractory hypotension

• Acute coronary syndrome within the last 3 months

• Previous use of dobutamine during the last 72 hours

• Cardiac index < 2.5 l/min/m2

• Non-sinus rhythm

• Heart rate >140 BPM

• Anticipated surgery or dialytic procedure during the study period

• Child B or C liver cirrhosis

• Hemoglobin < 8 gr/dl

• Uncontrollable fever > 39ºC