Effects of Doravirine (MK-1439) on Methadone Pharmacokinetics in Methadone-Maintained Participants (MK-1439-045)
Status:
Completed
Trial end date:
2016-08-15
Target enrollment:
Participant gender:
Summary
This study will evaluate the effects of multiple doses of doravirine (MK-1439) on the
pharmacokinetics of methadone in participants requiring methadone maintenance therapy. The
primary hypothesis is that area under the plasma concentration-time curve to 24 hours
postdose (AUC0-24) of (R)-methadone is similar when a maintenance regimen of methadone is
administered with or without multiple daily doses of doravirine.