Effects of EED on Zn Absorption and Retention in Children From a Standard Dose

• Status: Completed
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The overall objective is to determine the impact of EED on zinc absorption and homeostasis, and its impact on the absorptive capacity of vitamin A absorption of young children (18-24 months of age) in an austere setting with high rates of diarrhea, stunting, and micro-nutrient deficiencies.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Colorado, Denver
• Collaborator: International Centre for Diarrhoeal Disease Research, Bangladesh
• Treatments: Acetic Acid; Retinol acetate; Retinol palmitate; Vitamin A; Vitamins; Zinc; Zinc Sulfate

Criteria

Inclusion Criteria:

• Absence of apparent health problems that would impair ability to consume regular diet, to tolerate zinc supplements, or to comply with demands of metabolic studies

• Length for age Z-score (LAZ) between -1.5 to -3.0

• Hemoglobin (Hgb) ≥ 8

Exclusion Criteria:

• Outside age range

• Hgb < 8

• Chronic illness

• Recent diarrhea (within past 2 weeks, treated with supplemental zinc)

• Severe stunting and/or severe acute malnutrition (SAM): LAZ <-3; Weight-for-age Z-score (WHZ) <-3 or mid-upper arm circumference (MUAC) < 115 or edema