Effects of Empagliflozin in Reducing Oxidative Stress After Kidney Transplantation
Status:
Not yet recruiting
Trial end date:
2022-02-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to investigate the effect of empagliflozin on oxidative stress
in patients with type 2 diabetes after kidney transplantation. The association is examined by
comparing the difference in oxidative modifications before and after 90 days treatment with
25 mg empagliflozin plus insulin compared to insulin treatment. The study is randomised and
double-blinded. Each treatment group consists of 20 patients. Oxidative stress markers are
measured by serum level of superoxide dismutase activity ,lipid peroxidation assay kit,
glutathione assay, glutathione peroxidase activity , total antioxidant capacity assay oxidant
status , carbonyl content assay and bca protein assay . . A student t-test will be performed
to compare adding empagliflozin . The results will be published in a peer-review journal.