Effects of Epinephrine and Intravenous (I.V.) Needle on Cardiopulmonary Resuscitation (CPR) Outcome

• Status: Completed
• Trial end date: 2008-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Intravenous epinephrine has been part of the guidelines for cardiopulmonary resuscitation since the start. It improves outcome in animal studies, but has never been investigated in a controlled study in humans. Epidemiologic data indicate that it is an independent negative predictor for survival. If this is true in a controlled randomized study, it could be due to effects of the drug itself or more likely due to reduced quality of chest compressions and ventilations due to the time spent on placing an I.V. needle and injecting drugs.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Petter Andreas Steen
• Collaborators: Health Region East, Norway; Laerdal Medical; Norwegian Air Ambulance Foundation; Ullevaal University Hospital; University of Oslo
• Treatments: Amiodarone; Atropine; Epinephrine; Epinephryl borate; Racepinephrine

Criteria

Inclusion Criteria:

• Cardiac arrest out-of-hospital

Exclusion Criteria:

• <18 years old

• Trauma as cause of arrest