Effects of Eplerenone on Cardiovascular Disease in HIV (MIRACLE HIV Study)
Status:
Active, not recruiting
Trial end date:
2022-05-01
Target enrollment:
Participant gender:
Summary
HIV-infected individuals treated with antiretroviral medications are living longer, but have
an increased risk of heart disease when compared to non-HIV-infected individuals. A hormone
called aldosterone, which regulates blood pressure and sodium balance, is elevated in the HIV
population in association with with increased belly fat and altered glucose metabolism.
Elevations in aldosterone hormone may also be associated with abnormal blood flow,
inflammation, and coronary plaque in the heart. This study is being conducted to evaluate
whether therapies to reduce the actions of aldosterone may decrease the burden and
progression of heart disease in the HIV population.