Effects of Estrogen Deficiency on Energy Expenditure

• Status: Completed
• Trial end date: 2016-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

Menopause is associated with weight gain, but the reasons why are not clear. In this study, the investigators will determine if reducing estrogen levels causes a decrease in the ability of the body to produce heat. If so, this would suggest this is one way that menopause may cause weight gain.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Colorado, Denver
• Collaborator: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
• Treatments: Estrogens; Leuprolide

Criteria

Inclusion Criteria:

• Body mass index < 30 kg/m2

• Normal menstrual cycles

• Premenopausal

Exclusion Criteria:

• irregular menstrual cycles defined as 2 or more missed cycles in the previous year

• on hormonal contraceptive or menopausal therapy

• positive pregnancy test

• intention to become pregnant or start hormonal contraceptive therapy during the period of study

• lactation

• severe osteopenia or osteoporosis (i.e., proximal femur or lumbar spine t scores < -2.0)

• abnormal vaginal bleeding

• thyroid dysfunction

• uncontrolled hypertension

• exercising at least 30 minutes per day at a moderate to vigorous intensity >1 d/wk) over the past 6 months