Effects of Estrogen on Memory in Post-Menopausal Women and Patients With Alzheimer's Disease

• Status: Completed
• Trial end date: 2004-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

The goal of this study is to examine whether the administration of estrogen to post-menopausal women and women with mild to moderate Alzheimer's disease will enhance their memory and their capacity for learning.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Center for Research Resources (NCRR)
• Collaborators: Alzheimer's Association; Eisai Inc.; Pfizer
• Treatments: Donepezil; Estrogens; Progesterone

Criteria

Inclusion Criteria:

• Normal volunteers and women with mild Alzheimer's disease:

• Non-smoker

• No use of Hormone Replacement Therapy for at least one year

• No menses for at least one year

• Normal mammogram within the last year

• minimum age is 45 for patients with Alzheimer's disease; 50 for normal volunteers

• Maximum age is 85 for patients with Alzheimer's disease; there is no maximum age for normal volunteers.

Exclusion Criteria:

• Women who are currently taking estrogen therapy.

• Women who are smokers.

• Women who have had breast cancer.