Effects of Eszopiclone on Sleep-dependent Learning in Schizophrenia

• Status: Completed
• Trial end date: 2012-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will determine whether eszopiclone will normalize sleep patterns and restore sleep-dependent enhancement of motor skill learning in patients with schizophrenia. The investigators will compare subjects taking a placebo to those taking 3 mg of eszopiclone with regard to: sleep architecture and sleep latency as measured by actigraphy and polysomnography and sleep-dependent motor skill learning.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Collaborators: Beth Israel Deaconess Medical Center; Sunovion
• Treatments: Eszopiclone

Criteria

Inclusion Criteria:

• Clinically stable outpatients with DSM-IV diagnoses of Schizophrenia

Exclusion Criteria:

• History of neurologic or psychiatric disease other than schizophrenia

• Substance abuse or dependence within the past six months

• Other chronic medical conditions that affect sleep

• Pregnancy/breast feeding

• Hepatic impairment

• Treatment with metabolic inhibitors or inducers