Effects of Evening Dose of Immediate Release Methylphenidate on Sleep in Children With ADHD
Status:
Terminated
Trial end date:
2018-06-01
Target enrollment:
Participant gender:
Summary
Over 10% of children in the United States are diagnosed with ADHD, and nearly half of these
children have moderate to severe impairments in sleep, further exacerbating their already
impaired academic, emotional and social functioning. In children with ADHD, 34% of prescribed
sleep medications are antipsychotics that can cause marked weight gain and metabolic changes;
alternate medications have either been found to be ineffective, difficult to tolerate or are
largely unstudied in youth. Delayed sleep onset is strongly correlated with active symptoms
of ADHD and Oppositional Defiant Disorder (ODD), suggesting that better control of disruptive
behaviors could improve sleep patterns and this application will assess if the extension of
the therapeutic effects of CNS stimulants into the early evening improves sleep onset.