Effects of Exercise and Improved Nitric Oxide Bioavailability on Arteriovenous Fistula Maturation
Status:
Terminated
Trial end date:
2017-03-10
Target enrollment:
Participant gender:
Summary
This project will examine if enhancing Nitric Oxide (NO) bioavailability increases the rates
of arteriovenous fistula (AVF) maturation in end stage renal disease patients requiring
vascular access for hemodialysis. To enhance NO bioavailability the study team will utilize a
program of forearm exercise training, application of nitroglycerin ointment or both. Goals of
this study are (A) to measure if recruited subjects can tolerate the intervention protocols,
and determine if dependent variable measures, including surgery outcome, and measurement of
physiologic and biologic markers, can be obtained; (B) To measure subject compliance and
adherence rates for each of the intervention arms and testing visits; (C) To examine which
intervention or combination of interventions demonstrates the strongest preliminary effects
in order to estimate power for a pivotal intent to treat trial; and (D) explore group
differences in clinical vascular markers and biologic markers in vein tissue.
Phase:
N/A
Details
Lead Sponsor:
Duke University
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)