Effects of Exercise in Combination With Epoetin Alfa

• Status: Completed
• Trial end date: 2004-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study was to determine the effect of Epoetin alfa therapy (short term versus long term) with and without a home-based individualized exercise program that incorporated aerobic and strength resistance training for patients being treated with high-dose chemotherapy and autologous peripheral bloodstem cell transplantation (PBSC T) for multiple myeloma. The endpoints for the study included the number of attempts at and total number of days of stem cell collection, number of RBC and platelet transfusions during the transplantation period, time-to-recovery after transplantation, and response to intensive therapy for multiple myeloma.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Arkansas
• Collaborators: National Institutes of Health (NIH); Ortho Biotech Clinical Affairs, L.L.C.
• Treatments: BB 1101; Calcium heparin; Cisplatin; Cyclophosphamide; Dalteparin; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Doxorubicin; Epoetin Alfa; Etoposide; Heparin; Heparin, Low-Molecular-Weight; Liposomal doxorubicin; Melphalan; Thalidomide; Tinzaparin; Vincristine

Criteria

Inclusion Criteria:

• Those who were not at high risk for impending pathologic fracture or cord compression, as determined by magnetic resonance imaging and other radiology reports and physician assessments,and enrolled in Total Therapy treatment protocols were invited to participate in the study.

Exclusion Criteria:

Patients were excluded if they showed any of the following attributes/conditions:

• Inability to understand the intent of the study

• Current diagnosis with a major psychiatric illness

• Presence of microcytic or macrocytic anemia

• Uncontrolled hypertension

• Red cell transfusions within 2 weeks; and

• Recombinant epoetin alfa within 8 weeks of study enrollment.