Effects of Experimental Sleep Disturbances on Receptor Function of Study Drug
Status:
Recruiting
Trial end date:
2023-01-31
Target enrollment:
Participant gender:
Summary
The overall goal of this project is to determine whether common sleep disturbance patterns,
sleep continuity disturbance (SCD) and Sleep Fragmentation (SF), alter cerebral study drug
receptor availability, drug-based analgesia, and drug abuse liability. The investigators
specifically aim to: 1) evaluate whether experimental SCD and/or SF alter resting or
pain-evoked receptor binding potential in brain regions associated with pain inhibition; 2)
examine whether SCD and/or SF alters the analgesic response and abuse liability profile of a
study medication; and 3) determine whether receptor binding potentials in brain regions of
interest are associated with study medication analgesia and abuse liability. The
investigators will also evaluate the extent to which associations differ by sleep condition
or sex.
Phase:
Phase 2
Details
Lead Sponsor:
Johns Hopkins University
Collaborator:
National Heart, Lung, and Blood Institute (NHLBI)
Treatments:
Analgesics Analgesics, Opioid Central Nervous System Stimulants