Effects of Fat Emulsions on PNALD and Oxidative Stress in Premature Infants

• Status: Not yet recruiting
• Trial end date: 2021-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Abnormal liver function or cholestasis is the result of multiple factors, include low birth weight, smaller than gestational age, preterm birth, infection, lipid emulsion (LE) in parenteral nutrition (PN), insufficient enteral nutrition (EN) etc. Most are inevitable, but the LEs in PN can be selected. So the investigators compare two LEs, and want to see if the SMOF LE can improve hepatic index in preterm infants.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shanghai Jiao Tong University School of Medicine
• Treatments: SMOFlipid

Criteria

Inclusion Criteria:

• Premature infants (gestational age < 32 weeks) with birth weight < 1500g were admitted to NICU of Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China within 24 hours after birth

• No contraindications to parenteral nutrition

• Expected PN support for 14 days or more

• Parents or guardians agree

Exclusion Criteria:

• Parenteral nutrition support was provided prior to enrollment

• EN calorie for 10% or more

• Congenital intestinal structural/functional abnormalities

• Liver function damage caused by viral hepatitis, genetic metabolism and abnormal biliary tract

• Congenital or acquired immunodeficiency

• Complex congenital heart disease