Effects of Fish Oil and Colesevelam (STAIR7007)

• Status: Active, not recruiting
• Trial end date: 2021-07-30
• Target enrollment: 0
• Participant gender: All

Summary

If treatment of colesevelam, fish oil in conjunction with ezetimibe, will lead to further reduction in plasma plant sterol levels in sitosterolemia patients. We hypothesize that treatments with fish oil, colesevelam and ezetimibe will maximize decrease in plasma concentrations of sitosterol and other plant sterols in sitosterolemia patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Manitoba
• Treatments: Colesevelam Hydrochloride

Criteria

Inclusion Criteria:

1. Confirmed diagnosis of homozygous sitosterolemia as established by genotyping and/or clinical parameters

2. Receiving ezetimibe treatment

3. Over 8 years of age (no maximum)

4. Concomitant illnesses or conditions

Exclusion Criteria:

1. Pregnancy

2. Intellectual disability

3. Bowel or biliary obstruction

4. Known hypersensitivity to colesevelam or any ingredients of colesevelam