Effects of GABA-a-Agonists on Pain Mechanisms: An Experimental Study in Healthy Volunteers
Status:
Completed
Trial end date:
2010-06-01
Target enrollment:
Participant gender:
Summary
The investigators will use an intradermal capsaicin injection in the forearm to induce a
state of localized pain. This localized pain will be measured by different means, and
analysed locally and distally by so called quantitative sensory testing. The primary endpoint
of measure is the difference in pain perception with and without
benzodiazepines/GABA-Agonists around the injection point of capsaicin. The secondary
endpoints are to measure pain modulation locally and distally by different quantitative tests
as electricity, pressure pain thresholds, and ice water tests.
The investigators' hypothesis is that clobazam induces higher pain thresholds as placebo and
less sedation than the control medication clonazepam.