Effects of GABA-a-Agonists on Pain Mechanisms: An Experimental Study in Healthy Volunteers

• Status: Completed
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: Male

Summary

The investigators will use an intradermal capsaicin injection in the forearm to induce a state of localized pain. This localized pain will be measured by different means, and analysed locally and distally by so called quantitative sensory testing. The primary endpoint of measure is the difference in pain perception with and without benzodiazepines/GABA-Agonists around the injection point of capsaicin. The secondary endpoints are to measure pain modulation locally and distally by different quantitative tests as electricity, pressure pain thresholds, and ice water tests.

The investigators' hypothesis is that clobazam induces higher pain thresholds as placebo and less sedation than the control medication clonazepam.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital Inselspital, Berne
• Treatments: Clobazam; Clonazepam; GABA-A Receptor Agonists; Tolterodine Tartrate

Criteria

Inclusion Criteria:

• European males

• 18-55 years old

• non smoking status or less than 10 cigarettes per day

• no disease

Exclusion Criteria

• any medication

• any drug abuse

• diseases of any type