Effects of Gallopamil in Severe Asthma

• Status: Completed
• Trial end date: 2012-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Severe asthma is a difficult to treat disease, characterized by bronchial remodelling, which is an abnormal repair process that contributes to the development of poorly reversible airway narrowing. Such remodelling is now considered as one of the main prognostic factors. Gallopamil-sensitive calcium influx plays a key role in this remodelling process in vitro. The objective of this study is to compare the effects of gallopamil versus placebo on the bronchial smooth muscle remodelling in severe asthmatic patients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Bordeaux
• Treatments: Gallopamil

Criteria

Inclusion Criteria:

• Male or female aged more than 18 years

• Written informed consent

• Diagnosis of severe asthma according to ATS criteria

Exclusion Criteria:

• Smoker or former smoker

• Chronic viral infections (hepatitis, HIV)

• Aspergillosis

• Pregnancy

• Breastfeeding

• Contraindications to gallopamil or bronchoscopy