Effects of Gastric Antral Botulinum Toxin Injections in Obese Subjects
Status:
Completed
Trial end date:
2011-09-01
Target enrollment:
Participant gender:
Summary
Obesity is an important public health problem in the United States. The investigators
hypothesize that stomach injections of botulinum toxin A (BTA), delivered through an
endoscope using endoscopic ultrasound (EUS), may cause delayed gastric emptying, satiation,
and reduction in body weight. This protocol is designed to study the effects and safety of
gastric BTA injections. Subjects are randomized to receive placebo or one of two different
doses of BTA injected into the stomach during one endoscopy, performed via the mouth. Gastric
emptying, satiation, symptoms, psychological dimensions of eating behavior, and caloric
intake are recorded before and after injections, and subjects are seen in follow-up for 24
weeks.