Overview

Effects of Gastric pH on the Pharmacokinetics of Dasatinib

Status:
Completed
Trial end date:
2014-02-01
Target enrollment:
Participant gender:
Summary
The goal of this study is to evaluate the ability of a natural supplement (betaine hydrochloride) to affect the absorption of dasatinib in healthy volunteers. The investigators predict that betaine hydrochloride will increase the absorption of dasatinib, in volunteers pre-treated with proton-pump inhibitors (PPIs).
Phase:
Phase 1
Details
Lead Sponsor:
University of California, San Francisco
Collaborator:
Genentech, Inc.
Treatments:
Betaine
Dasatinib
Rabeprazole