Effects of Glucagon Like Peptide-1(GLP-1) and Liraglutide on Brain Satiety and Reward Circuits and Feeding Behavior in Diabetes

• Status: Completed
• Trial end date: 2015-01-01

Summary

The aim of this study is to investigate if endogenous Glucagon Like Peptide -1 (GLP-1) has an effect on brain satiety and reward systems and if there are alterations in obese patients with type 2 diabetes (T2DM). Secondly, the aim is to investigate whether treatment with a GLP-1 analog, liraglutide, restores these signals in obese patients with type 2 diabetes. Finally, also the endogenous GLP-1 effects will be investigated in obese individuals before and after gastric bypass surgery on brain satiety and reward systems.

• Phase: N/A

Details

• Lead Sponsor: VU University Medical Center
• Treatments: Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Glargine; Insulin, Globin Zinc; Liraglutide