Effects of Glucocorticoid Combined With Vitamin C and Vitamin B1 on Microcirculation in Severe Septic Shock

• Status: Completed
• Trial end date: 2020-01-30
• Target enrollment: 0
• Participant gender: All

Summary

This study aimed to investigate the effect of Glucocorticoid combined with vitamin C and vitamin B1 versus hydrocortisone alone on microcirculation in septic shock patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Southeast University, China
• Treatments: Ascorbic Acid; Cortisol succinate; Glucocorticoids; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate; Hydrocortisone hemisuccinate; Thiamine; Vitamin B Complex; Vitamins

Criteria

Inclusion Criteria:

1. Septic shock

2. A dose of norepinephrine (>15ug/min)

3. Age ≥18 and ≤80 years old

4. Signing Informed Consent

Exclusion Criteria:

1. Meet the inclusion criteria for more than 12 hours

2. Clinician judges that corticosteroid therapy should not be used

3. Pregnant

4. Uncontrolled malignancy

5. Glucocorticoid therapy was used within seven days before admission.

6. Expected death within 24 hours

7. The sublingual microcirculation cannot be measured