Effects of Growth Hormone on the Nitric Oxide Pathway

• Status: Completed
• Trial end date: 2005-01-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of the study is to determine whether the treatment with growth hormone has an influence on the nitric oxide pathway in healthy males.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hannover Medical School
• Collaborator: Pharmacia
• Treatments: Hormones; Nitric Oxide

Criteria

Inclusion Criteria:

• Healthy male subjects without recent severe diseases

• Age 50 yrs or older

• Body mass index at or below 30 kg/m2

• Insulin-like growth factor-1 level below 200 ng/ml

• Evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the trial

• Subjects that are willing and able to comply with scheduled visits, treatment plan, laboratory tests and other study procedures

Exclusion Criteria:

• History of any severe hepatic, renal, cardiac, endocrine, metabolic, or malignant diseases

• Requirement for medical drug treatment

• Growth hormone treatment during the last 12 months

• Drug dependence, alcohol or nicotine abuse

• Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or may interfere with the interpretation of study results and, in the judgement of the investigator, would make the subject inappropriate for entry into this study.