Effects of Heart Rate Reduction on Central Arterial Pressure in Healthy Individuals

• Status: Terminated
• Trial end date: 2011-11-08
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this project is to determine the effects of slowing heart rate upon both central and peripheral blood pressures using Ivabradine. The effects of Ivabradine will be compared to Metoprolol and placebo.

Participants will attend the hospital for 3 visits where they will be randomised to receive either Ivabradine, Metoprolol and placebo on each visit. Non-invasive measures of blood pressure will be recorded before and after consuming the study drug.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Bayside Health
• Collaborator: Baker Heart and Diabetes Institute
• Treatments: Metoprolol

Criteria

Inclusion Criteria:

Healthy volunteers:

• aged 18 - 25 years OR

• aged >60 years

Exclusion Criteria:

• Chronic disease

• Unable to give informed consent

• Treated or untreated systemic arterial hypertension (SBP >160mmHg and/or DBP > 90mmHg)

• Resting bradycardia (heart rate < 60 beats/minute)

• Pregnancy or active lactation