Effects of High Dose Atorvastatin in Patients With Surgical Aortic Stenosis
Status:
Unknown status
Trial end date:
2018-01-01
Target enrollment:
Participant gender:
Summary
The purpose of the study is to see if statin therapy will optimize myocardial response to
cardiopulmonary bypass during aortic valve replacement (AVR) for aortic valve stenosis (AVS)
(Phase I) and optimize left ventricular reverse remodeling following AVR (Phase II).
Preliminary evidence indicates that perioperative statin therapy reduce mortality and
morbidity following cardiac surgery. Pleiotropic effects of statins may induce myocardial
preconditioning and optimize myocardial and systemic responses to cardiopulmonary bypass
during AVR. Furthermore statin therapy after AVR may contribute to an optimal left
ventricular reverse remodeling.