Effects of High-dose Intravenous Selenium (Selenase®) in Adult Patients Subjected to Elective All-cause Heart Surgery
Status:
Completed
Trial end date:
2012-09-01
Target enrollment:
Participant gender:
Summary
Selenoenzymes play a major role in protecting cells against lipid peroxidation and they are
involved in the inflammatory response regulation. The degree of selenium deficiency
correlates with disease severity and the incidence of mortality in critically ill patients.
The aim of our study is to evaluate, if high dosis selenium supplementation (loading dose
4000 μg, daily dosage 1000 μg) results in a significant reduction of inflammation-induced
organ dysfunction and length of ICU-stay in patients after heart surgery.