Effects of Hyperbaric Oxygen Therapy on Surgical Wound Healing
Status:
Unknown status
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
The aim of this study is to test the effect of Hyperbaric Oxygen Therapy) HBOT (100% oxygen;
2.0 ATA; 90 minute total exposure) and compare against a hyperbaric sham treatment (HBST)
(patient's breathing room air; 2.0 ATA; 90 minute exposure) in reducing edema and ecchymosis.
HBOT will be applied as a single pre-operative and a single post-operative treatment for
patients undergoing eyelid surgery. Briefly, patients will be exposed to HBOT 2-4 hours prior
to undergoing surgery, 2-4 hours post-surgery and healing will be assessed at day 3, 10, 21,
30 & 90 days after surgery. Edema and ecchymosis will be assessed in a time series to
determine the extent that HBOT reduces these clinical signs. The primary null hypothesis to
test will be that no differences in scores will exist between treatment and control at day 3,
10 & 21 post-surgery. A secondary null hypothesis to test is the time required to change a
score will be no different between the two groups.
HBOT=hyperbaric oxygen therapy; HBST=hyperbaric sham treatment