Effects of Hypolipemic Treatment on Adipokines

• Status: Completed
• Trial end date: 2009-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The study is planned to show whether monotherapies or combined hypolipemic therapy influence the fasting plasma glucose, serum adipokines (leptin, adiponectin, resistin) and proinflammatory cytokines (interleukin-6, TNF alpha) during 30 and 90 day course.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Medical University of Silesia
• Collaborator: Ministry of Scientific Research and Information Technology, Poland
• Treatments: Atorvastatin Calcium; Fenofibrate

Criteria

Inclusion Criteria:

• Age (35-64yr)

• Primary hyperlipidemia (Total cholesterol >200mg/dl, Triglycerides >150mg/dl)

• Impaired fasting glycemia (glycemia 100-125mg/dl)

• For women:

• Menopause (>12 months)

• Post hysterectomy

• Mechanical contraception

• Obtained informed consent

Exclusion Criteria:

• Secondary hyperlipidemia

• Morbid obesity (BMI>40kg/m2)

• Alcohol or drug abuse

• Acute or chronic inflammation

• Congestive Heart Failure (NYHA III or IV)

• Unstable Ischaemic Heart Disease

• Moderate or severe hypertension

• Cancer in less than 5 years

• Chronic kidney disease (stage III-V)

• Liver failure

• Diabetes

• Oral contraception

• Not compliant patient

• Laboratory results:

• alanine transferase (>3xULN)

• creatine kinase (>5xULN)

• haemoglobin (<10/dl)

• PLT (<100G/l)

• WBC (<3,5G/l or >10G/l)