Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance
Status:
Completed
Trial end date:
2007-12-01
Target enrollment:
Participant gender:
Summary
Subjects with impaired glucose tolerance will be randomized to receive pioglitazone or
metformin for 10 weeks. Measurements of insulin sensitivity, body composition, glucose
tolerance, and muscle lipid accumulation will be performed. Adipose tissue and muscle
biopsies are performed. The goal of the study is to determine whether the lipotoxiciy of
impaired glucose tolerance is ameliorated by pioglitazone.
Phase:
Phase 4
Details
Lead Sponsor:
US Department of Veterans Affairs VA Office of Research and Development