Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance

• Status: Completed
• Trial end date: 2007-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Subjects with impaired glucose tolerance will be randomized to receive pioglitazone or metformin for 10 weeks. Measurements of insulin sensitivity, body composition, glucose tolerance, and muscle lipid accumulation will be performed. Adipose tissue and muscle biopsies are performed. The goal of the study is to determine whether the lipotoxiciy of impaired glucose tolerance is ameliorated by pioglitazone.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: US Department of Veterans Affairs; VA Office of Research and Development
• Treatments: Metformin; Pioglitazone

Criteria

Inclusion Criteria:

• Impaired glucose tolerance

• Body mass index (BMI) of 28-38

Exclusion Criteria:

• Heart disease

• Renal disease

• Liver disease