Effects of Insulin Treatment on Postprandial Platelet Activation in Patients With Non-insulin-dependent Diabetes Mellitus (NIDDM)

• Status: Completed
• Trial end date: 2010-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The postprandial phase in diabetic patients is characterized by a rapid increase in blood glucose levels, increase in platelet aggregation, LDL oxidation and over production of thrombin.

The aim of the study is to determine whether meal induced platelet activation is related to post-prandial hyperglycemia, and can be attenuated by good postprandial glucose control with rapidly acting insulin in patients with T2DM.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Karolinska Institutet
• Treatments: Insulin; Insulin Aspart; Insulin degludec, insulin aspart drug combination; Insulin, Globin Zinc; Insulin, Long-Acting

Criteria

Inclusion Criteria:

• Type II Diabetes Mellitus.

• Antecubital forearm veins allowing technically good sampling for platelet studies.

• HbA1c 6-9 % (Mono-S method).

• Below 70 years

Exclusion Criteria:

• History of a cardiovascular disease; Ischemic heart disease, Stroke, Peripheral vascular disease.

• Acute or chronic renal or liver disease

• Contraindication to insulin treatment

• Treatment with Glitazones, Sulphonylurea, antiplatelet drugs,

• Thrombocytopenia <150 X109/l.