Effects of Intensive Long-Term Vasodilation in Hypertensive Patients With Microvascular Angina Pectoris

• Status: Terminated
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if long-term vasodilatory treatment is more effective than the standard treatment in hypertensive patients with microvascular angina pectoris

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Aarhus
• Collaborators: Danish Cardiovascular Research Academy; Danish Heart Foundation; Novartis
• Treatments: Amiloride; Doxazosin; Hydrochlorothiazide; Lercanidipine; Moxonidine; Nicorandil; Pindolol; Valsartan

Criteria

Inclusion Criteria:

• hypertension

• angina pectoris CCS class II-IV

• objective signs of ischemia on exercise-ECG or myocardial SPECT

• no significant stenosis on angiography (minimal lumen diameter >50% of relevant reference segment)

Exclusion Criteria:

• known allergy to any study medication

• abnormal lab tests of clinical significance

• valvular disease of haemodynamic significance

• known secondary hypertension

• atrial fibrillation or other significant arrythmias

• myocardial infarction < 30 days before inclusion

• resting angina < one week before inclusion

• known endocrine disease, nephropathy or hepatic disease

• present malignant disease

• pregnancy

• fertile women not using safe contraceptives > 6 months before inclusion. Use of contraceptives must continue 1 month after completion or retraction from the study

• body mass index > 30

• significant chronic obstructive lung disease (FEV1 < 1.5 l)

• participant in another study including test medicine

• present treatment with dipyridamole

• present treatment with phosphodiesterase-5-inhibitors that the patient does not want to discontinue during the study period

• heart transplanted patients

• patients with magnetizable metallic implants