Effects of Intensive Statin Treatment on Left Ventricular Function

• Status: Unknown status
• Trial end date: 2014-07-01
• Target enrollment: 0
• Participant gender: All

Summary

First acute anterior myocardial infarction in patients with primary PCI preoperative and postoperative 30 days intensive dose atorvastatin statin therapy compared with conventional -dose therapy , patients can improve left ventricular function , reduce major adverse cardiovascular events .

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shenyang Northern Hospital
• Treatments: Atorvastatin; Atorvastatin Calcium; Hydroxymethylglutaryl-CoA Reductase Inhibitors

Criteria

Inclusion Criteria:

1. ≥ 18 years of age

2. the first time clinical diagnosis of acute anterior myocardial infarction , the time of onset ≤ 12 hours ,intends underwent emergency PCI

3. informed consent

Exclusion Criteria:

1. Taking , or the need for long-term use of statins is greater than the initial dose

2. treated with PCI again within a mouth

3. active liver disease or liver dysfunction

4. the diagnosis of myopathy

5. severe renal insufficiency ( serum creatinine > 178umol / L )

6. Statin drug allergy or had a serious adverse reaction

7. severe aortic stenosis or mitral stenosis , hypertrophic obstructive cardiomyopathy , pericardial disease

8. pregnancy

9. malignancy or any other end-stage diseases result in a life expectancy of < 6 months

10. be participating in other clinical studies

11. not suitable for inclusion of the other cases

12. not treated with PCI