Effects of Intraarterial Octreotide on Pancreatic Texture

• Status: Completed
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to test the hypothesis that intraarterial bolus application of 500 µg Octreotide in the gastroduodenal artery during the resectional phase of pancreatoduodenectomy in patients with soft pancreatic tissue hardens the texture of the pancreatic remnant.

A primary end-point of the study is a change in pancreatic texture.

A secondary end-point is the rate of postoperative pancreatic fistula.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: St. Josef Hospital Bochum
• Treatments: Octreotide; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• age between 18 an 90 years

• planned pancreatoduodenectomy

• signed informed consent

• pancreatic hardness equal or less than 40 SU as measured by durometer

• normal vascular anatomy of the hepato-pancreatic region

Exclusion Criteria:

• planned distal pancreatic resection

• planned non-resectional pancreatic surgery

• acute pancreatitis at the time of surgery

• pancreatic hardness before intervention higher than 40 SU as measured by durometer

• intraoperatively unstable patient

• intraoperative complications

• allergy towards octreotide

• anatomical variation of the vascular supply of the liver or pancreas posing an increased risk for octreotide distribution in other organs than pancreas

• lacking gastroduodenal artery or technically impossible cannulation of the artery