Effects of Intranasal Oxytocin Administration on Social Influence Effects on Pain

• Status: Completed
• Trial end date: 2019-04-01
• Target enrollment: 0
• Participant gender: All

Summary

This experiment will explore the joint effects of social information, social support, associative learning, and oxytocin on the development of placebo analgesia. The investigators predict that socially transmitted placebo effects will be enhanced by nasal administration of oxytocin, whereas associative learning effects on pain will not be altered by this pharmacological manipulation

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Colorado, Boulder
• Treatments: Oxytocin

Criteria

Inclusion Criteria:

• Subject is a volunteer between 18 and 40 years of age.

• If female, subject is non-lactating, not pregnant, and using a reliable contraception method

• Subject is able to read and speak English.

• Subject is able and willing to provide written informed consent.

• Subject is able to understand and follow the instructions of the investigator and understand all screening questionnaires.

• Subject is in good health.

• For participants to be eligible for all tasks of the study, the participant must have a romantic partner and be willing to bring the partner to the study session.

Exclusion Criteria:

• Tests positive on the 14 panel poly-substance urine drug screen for illicit substances (e.g., marijuana (THC), cocaine (COC), phencyclidine (PCP), amphetamine (AMP), ecstasy (MDMA), methamphetamine (Mamp), opiates (OPI), oxycodone (OXY), methadone (MTD), barbiturates (BAR), benzodiazepines (BZO), buprenorphine (BUP), tricyclic antidepressants (TCA), propoxyphene (PPX))

• Chronic Pain

• Do not have the ability to tolerate heat pain applied to the forearm

• Have temporary abnormal levels of pain

• Have score of > 19 using the Center for Disease and Epidemiology Depression Scale

• Current treatment (e.g., medications or therapy) for psychiatric disorders, including mood, anxiety, substance abuse, Attention-deficit/hyperactivity disorder (ADHD), psychosis; Neurological disorders (e.g., taking dopamine agonists for Parkinson's); Cardiovascular disease or medication (e.g., taking ACE (angiotensin-converting-enzyme) inhibitors for cardiac remodeling)

• Frequent smoking (> 5 cigarettes / day); frequent alcohol use (>14 drinks / week); frequent migraines (> 5 / month on average) or a history of neurologic disease or neuropathic pain.

• Any allergy to Oxytocin