Effects of Intraoperative, Goal-directed Crystalloid vs. Colloid Fluid Resuscitation on Free Flaps

• Status: Completed
• Trial end date: 2018-09-19
• Target enrollment: 0
• Participant gender: All

Summary

Maintaining satisfactory tissue perfusion is an essential of success during reconstructive free flap surgery following malign oral cavity tumours. Intra- and postoperative goal-directed fluid therapy is an appropriate tool for that. Continuous cardiac output monitoring based fluid loading (complemented with vasopressor and/or inotropes if necessary) might be superior to conventional, central venous and arterial pressure monitoring in terms of morbidity, complications, optimal fluid balance and days spent in hospital. However, there is no data describing the effects of goal-directed fluid therapy (crystalloid or colloid) on microcirculation of free flaps implanted in the oral cavity during the post-operative period. The aim of this study is to observe the effects of continuous macrohaemodynamic monitoring based, goal-directed fluid therapy on microcirculation of forearm flaps during the perioperative period.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Szeged University
• Collaborators: Department of Oral and Maxillofacial Surgery, University of Szeged; Institute of Surgical Research, University of Szeged
• Treatments: Dobutamine; Norepinephrine

Criteria

Inclusion Criteria:

• Age over 18

• Tumour location: intraoral

• Free flap type: radial forearm

• Signed informed concent form

Exclusion Criteria:

• Vulnerable subject as defined in International Standards Organization 14155:2011

• End stage oral cancer