Effects of Intraoperative Normal Saline vs Lactated Ringer on Outcomes in Pediatric Liver Transplantation
Status:
Unknown status
Trial end date:
2020-05-27
Target enrollment:
Participant gender:
Summary
Lactated Ringer(LR) has been extensively used to maintain and replace intravascular volume in
a variety of anesthetic procedures. However, the utility of LR in pediatric with hepatic
failure undergoing liver transplantation is unclear, because addition of exogenous lactate
may increase lactate concentration. In addition,large amounts of normal saline(NS) which does
not contain lactate can induce a hyperchloremic metabolic acidosis and have been asociated
with adverse effects on kidney injury, coagulation, and death. Accordingly, the investigators
performed a double-blinded randomized trial comparing the effects of intraoperative NS or LR
on outcomes in pediatric receiving Liver transplantation.