Effects of Intravenous Administered Iron in Non-anemic Iron Deficient Patients With Colorectal Cancer
Status:
Not yet recruiting
Trial end date:
2029-03-01
Target enrollment:
Participant gender:
Summary
This double-blinded clinical randomized trial with a 1:1 recruitment ratio between placebo
and the active group will aim to investigate the effects of intravenously administered iron
in non-anemic iron deficient patients on physical capacity, immunological cells and their
function prior to surgery. A total of 134 patients with colorectalcancer will be included in
the study.
Study outline:
After initial inclusion the patient will undergo baseline testing with cardiopulmonary
exercise test (CPET), then followed by an infusion of a weight dependent dosage of
iron(III)isomaltoside or placebo. Then at the closest possible time to the surgery the
patient will have drawn bloodwork and be re-tested by (CPET). The patient will be followed
after surgery with evaluation of several outcomes including quality of recovery and
complications. Further, the effects of the intervention on the patients immune function will
be evaluated by two different methods: 1) by changes in neutrophil-to-lymphocyte ratio
between baseline and preoperative bloodwork and 2) by evaluation mRNA expression in the tumor
specimen by the Nanostring pancancer immune panel