Effects of Intravenous Lidocaine on ED50, ED95 and NTI Values of Propofol Induced Unconsciousness

• Status: Not yet recruiting
• Trial end date: 2022-11-25
• Target enrollment: 0
• Participant gender: All

Summary

The effect of intravenous lidocaine on ED50 and ED95 of propofol, which causes unconsciousness, is unclear. In addition, it is not clear whether the depth of anesthesia induced by propofol changes when lidocaine is used in combination. Therefore, the purpose of this study was to study the effects of intravenous lidocaine on ED50, ED95 and NTI values of propofol induced unconsciousness .

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: General Hospital of Ningxia Medical University
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

1. The informed consent is signed

2. Aged 18 to 65 years old

3. ASA is rated from I to II

4. Body mass index ranged from 18.5 to 24.9 kg/m2

Exclusion Criteria:

1. Unwilling to sign informed consent or refuse to participate in the study

2. Patients with serious arrhythmia and organic heart disease before surgery

3. Sedative and analgesic drugs were taken within 1 week before surgery

4. Lidocaine allergy

5. Patients with mental and neurological diseases

6. Patients with difficult airway

7. People with hearing impairment