Effects of Intravenous Lidocaine on Transperitoneal Laparoscopic Urological Surgery

• Status: Completed
• Trial end date: 2011-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Effective perioperative analgesia is the key to postoperative rehabilitation. An intriguing body of evidence suggests that short-term administration of intravenous lidocaine may produce pain relief that far exceeds both the duration of infusion and the half-life of the drug. When pain relief is provided, concomitant anal-gesic medication can be reduced, side effects from pain relieving medication minimized with a potential for a more rapid postoperative recovery and less complications. IV application of lidocaine should de-crease the duration of bowel dysfunction. We hypothesise that i.v. application of lidocaine in a standard antiarrythmic dose can significantly improve acute rehabilitation after laparoscopic urological surgery and so shorten the hospital stay (primary outcome). We expect that the intraoperative inflammatory response can significantly be reduced.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Inselspital, Berne
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• Written informed consent

• ASA 1 to 3

• Laparoscopic transperitoneal urological surgery

Exclusion Criteria:

• Liver insufficiency

• Steroid therapy

• Chronic opioid therapy

• Allergy to lidocaine

• Pre-existing disorder of the gastrointestinal tract

• AV-block II-III, sinusbradycardia, heart insufficiency, long QT-syndrome

• Pregnancy