Effects of Iron Loading and Iron Chelation Therapy on Innate Immunity During Human Endotoxemia
Status:
Completed
Trial end date:
2010-09-01
Target enrollment:
Participant gender:
Summary
Iron affects immunity. However, the exact effect of iron on the innate immune response is not
known. Animal data suggest that iron administration induced oxidative stress which enhances
the innate immune response, whereas iron chelation has the opposite effect. The investigators
tested the hypothesis that administration of iron sucrose 1.25 mg/kg augments the innate
immune response, and iron chelation by deferasirox 30 mg/kg attenuates the innate immune
response during human experimental endotoxemia.
Phase:
N/A
Details
Lead Sponsor:
Radboud University
Collaborator:
ZonMw: The Netherlands Organisation for Health Research and Development
Treatments:
Deferasirox Ferric Compounds Ferric Oxide, Saccharated Iron