Effects of Iron Therapy and Exercise Training in Patients With Heart Failure and Iron Deficiency

• Status: Suspended
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

It is the aim of the study to prove, if intravenous supplementation with ferric carboxymaltose in iron-deficient patients with heart failure with reduced ejection fraction (HFrEF) leads to better exercise training effects compared to exercise training without previous iron supplementation.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Herzzentrum Bremen
• Treatments: Iron

Criteria

Inclusion Criteria:

• Heart failure with reduced ejection fraction ≤ 40%

• New York Heart Failure Asssociation class II-III

• Iron deficiency (ferritin < 100 ng/ml or 100-299 ng/ml, if transferrin saturation < 20%)

Exclusion Criteria:

• Planned cardiovascular interventions (such as bypass surgery or valve interventions)

• Acute coronary Syndrome

• Malignant rhythm disturbances

• Acute or chronic infection

• Reduced prognosis or exercise capacity by non-cardiac comorbidities

• Missing informed consent