Effects of Ketamine on Eye Movements, Perception and Brain Function

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

In this study, the investigators examine the effects of low-dose ketamine on different oculomotor, perceptual and cognitive functions. They also examine effects on concurrent brain activity using blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI). A sample of N=25 healthy, male participants is required to complete the study. The design is within-subjects, placebo-controlled, double-blind and cross-over. A targeted ketamine level in plasma of 100ng/ml is applied. It is hypothesised that ketamine, compared to placebo, will lead to changes in task performance and brain activity similar to those observed in patients with schizophrenia.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Bonn
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• MRI-suitability

• suitability for video-based combined pupil and corneal reflection (VCPCR) eye-tracking

• good command of German language

• willingness to take part

Exclusion Criteria:

• any current or history of axis I disorder diagnosis as assessed by the Mini-International Neuropsychiatric Interview (M.I.N.I.)

• any neurological conditions and heart conditions

• use of any prescription or non-prescription medication up to one week before participation

• personal history of head-injuries, loss of consciousness, eye surgery or impairment of vision (other than corrective lenses)

• any other relevant medical conditions such as high blood pressure

• positive urine drug test (Drug-Screen Multi "5T", nal von minden GmbH)

• history of drug use or current drug use

• under- or overweight (below 18.5 and above 24.9 body mass index (BMI) values)

• any diagnosis of psychotic disorders among first-degree relatives