Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females

• Status: Completed
• Trial end date: 2019-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

Because of these anabolic properties of ketone bodies and the fact that ketone bodies prevent muscle protein breakdown for gluconeogenesis during energetic stress, ketone bodies can be a promising strategy to prevent or treat skeletal muscle wasting. Therefore, our aim is to investigate the effect of 3HHB intake on muscle wasting and its adverse consequences during a period of caloric restriction in lean females. In addition, we compare the effects of 3HHB intake with a high protein diet, which is currently considered as the best strategy to minimize lean loss during hypo-energetic periods. To end, we aim to investigate the synergistic effects of the intake of 3HHB in combination with a high protein diet.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: KU Leuven

Criteria

Inclusion Criteria:

• Females between 18 and 40 years old

• Fat percentage between 16 and 25%

• Regularly involved in physical activity ( > 6 h/week)

• Use of hormonal contraceptives

• Good health status confirmed by a medical screening

• Stable body weight during the last 3 months prior to the study, i.e. no changes > 2 kg

Exclusion Criteria:

• Smoking

• Obsessive pursuit for thinness, evaluated by the Eating Disorder Inventory 3 (EDI-3) 'Pursuit of leanness' (i.e a score higher than 26/32) (see Appendix 5)

• Intake of any medication or nutritional supplement that is proven to affect exercise performance, except oral contraceptives

• Blood donation during the study

• Current participation in another research trial

• Any other argument to believe that the subject is unlikely to successfully complete the full study protocol