Effects of L-arginine on Myocardial Energetic Efficiency and Global Longitudinal Strain

• Status: Recruiting
• Trial end date: 2021-08-30
• Target enrollment: 0
• Participant gender: All

Summary

The study is designed to evaluate the effects of L-arginine on myocardial structure and function and circulating microRNAs in patients with arterial hypertension.

The study will analyze the impact of 4 weeks treatment randomized to L-arginine or placebo, on mechanical-energy efficiency (MEE) and longitudinal strain in patients with arterial hypertension. The investigators will also assess whether the changes in MEE and strain induced by L-arginine treatment is associated with changes in circulating micro RNAs.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Federico II University
• Collaborators: Prof. Costantino Mancusi; Prof. Raffaele Izzo

Criteria

Inclusion Criteria:

• Low values of mechanical-energy efficiency

• Sinus rhytm

Exclusion Criteria:

• Atrial fibrillation

• Taking Beta blockers

• Pregnancy

• Cancer