Effects of L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Hypothyroidism
Status:
Active, not recruiting
Trial end date:
2023-07-01
Target enrollment:
Participant gender:
Summary
Hypothyroidism is a common clinical entity which is often complicated by dyslipidemia. It is
also reported increased risk for incidence of atherosclerosis and resulting coronary heart
disease(CHD), heart failure(HF) and cardiovascular(CV) death. The effect of L-thyroxine
replacement treatment on serum lipid and atherosclerosis is controversial in hypothyroid
patients, especially in those with mild or moderate subclinical hypothyroidism. The present
study was designed to investigate whether L-thyroxine replacement was effective in improving
serum lipid profiles and retarding atherosclerosis progress.